CARDIOMYOCYTE OGA HAPLOINSUFFICIENCY INCREASES O-GLCNACYLATION BUT HASTENS VENTRICULAR DYSFUNCTION FOLLOWING MYOCARDIAL INFARCTION.

Cardiomyocyte Oga haploinsufficiency increases O-GlcNAcylation but hastens ventricular dysfunction following myocardial infarction.

RationaleThe beta-O-linkage of N-acetylglucosamine (i.e., O-GlcNAc) to proteins is a pro-adaptive response to cellular insults.To this end, increased protein O-GlcNAcylation improves short-term survival of cardiomyocytes subjected to acute injury.This observation has been repeated by multiple groups and in multiple models; however, whether increase

read more